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G protein-coupled bile acid receptor TGR5 activation inhibits kidney disease in obesity and diabetes

It is going to take a lot for someone to wrestle that away from them, at least in the near future. And as for amylin analogs, Papamargaritis, the Leicester researcher, says that, based on current data, Lillys molecule is leading in terms of the amount of weight loss it can offer, but that doesnt mean the market doesnt have a place for other amylin analogs as well as drugs that target other receptors, such as glucagon

Why compounded GLP-1 drugs exist in the first place According to the study, copycat drugs mimicking the effects of Wegovy, Zepbound and other popular weight-loss drugs were legally compounded starting in 2022, after the FDA placed the brand-name versions on its official drug shortage list

doi:10.1016/j.canlet.2008.12.027 101

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